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KMID : 0387720120230010013
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Korean Journal of Blood Transfusion
2012 Volume.23 No. 1 p.13 ~ p.19
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Evaluation of RF300 for Leukoreduction of Red Blood Cells
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Kwon So-Yong
Cho Nam-Sun
Song Sun-Nyeo
Lee Ju-Yeon
Lim A-Hyun
Lee Hyeon-Mi
Ji Yeong-Cheon
Seo Chang-Sik
Park Yun-Hui
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Abstract
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Background: Use of universal leukoreduction for prevention of leukocyte associated transfusion reactions is common practice in many countries. This study was conducted in order to evaluate the performance of a newly developed leukoreduction filter for red blood cells (RBCs), the RF300 (Kolon Industries, Inc, Gumi, Korea).
Methods: Filtration time, RBC recovery, residual leukocyte count, and leukocyte removal rate were evaluated. To assess the quality of RBCs after filtration, percent hemolysis was monitored for a period of 21 days. Performance of the RF300 (N=78) was compared with that of the Bio-R O2 plus (Fresenius, Hamburg, Germany), the Pall Purecell RC (Pall Co., Washington, USA), and the Sepacell R-500N (Asahi, Tokyo, Japan).
Results: The shortest filtration time was observed using the RF300 (P＜0.05). Using the RF300, recovery of RBC was 96.5%, which was higher than that of two filters (P＜0.05). Mean residual leukocyte count was 0.26×106/unit, with a leukocyte removal rate of 3 log. Using the RF300, mean percent hemolysis was 0.32% at day 21, which was comparable with that of two filters, but lower than that of one filter (P＜0.05).
Conclusion: The RF300 meets all established quality requirements for conduct of safe and effective leukoreduction of RBCs.
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KEYWORD
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RF300, Leukoreduction, Red blood cells
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